Research Library
Scientific references on blood sugar & metabolic health
17 peer-reviewed systematic reviews, meta-analyses, and clinical guidance documents, organized by topic. Every link opens the original source.
01Microbiome
Microbiome-modulating probiotics, prebiotics & synbiotics on glucose homeostasis in type 2 diabetes
A systematic review and meta-regression of clinical trials evaluating how gut-microbiome-targeted supplementation relates to fasting glucose, HbA1c, and insulin measures.
Pharmacological Research2022
Read on PubMed →
02Microbiome
Probiotics & synbiotics supplementation and glycemic control in prediabetes and type 2 diabetes
A GRADE-assessed systematic review and meta-regression of randomized clinical trials on probiotic and synbiotic supplementation and glycemic markers.
Pharmacological Research2022
Read on PubMed →
03Microbiome
Probiotics, prebiotics, synbiotics and insulin sensitivity
A review of human clinical trials and proposed mechanisms behind how gut-microbiota-targeted interventions may relate to insulin resistance.
Proceedings of the Nutrition Society
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04Botanical Research
Gymnema sylvestre supplementation and glycemic control in type 2 diabetes
A systematic review and meta-analysis of 10 studies examining fasting glucose, post-meal glucose, and HbA1c after Gymnema sylvestre supplementation.
Phytotherapy Research2021
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05Nutrition
Chromium supplementation and glycemic control in type 2 diabetes
A systematic review and meta-analysis of randomized controlled trials on chromium supplementation and fasting glucose, insulin, and HbA1c.
Pharmacological Research2020
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06Nutrition
Chromium supplements for glycemic control: limited evidence of effectiveness
A more cautious review concluding that evidence for chromium's effect on glycemic control remains limited and inconsistent across trials — included here for balance.
Nutrition Reviews2016
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07Botanical Research
Cinnamon use in type 2 diabetes: an updated systematic review
Found reductions in fasting glucose and lipid markers, but no statistically significant effect on HbA1c — a good example of why evidence needs to be read in full.
Annals of Family Medicine2013
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08Botanical Research
Cinnamon and glycemic control: an umbrella meta-analysis
Pooling 11 prior meta-analyses, this umbrella review found cinnamon supplementation associated with reductions in fasting glucose, insulin, and HOMA-IR.
Diabetology & Metabolic Syndrome2023
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09Botanical Research
Green tea consumption and glycemic control: a systematic review
Found a small reduction in fasting glucose, but no significant effect on fasting insulin or HbA1c — evidence for green tea remains genuinely mixed.
Diabetology & Metabolic Syndrome2020
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10Nutrition
Dietary approaches and glycemic control: a network meta-analysis
Compared 10 dietary patterns across 42 RCTs; ketogenic, low-carbohydrate, Mediterranean, and low-glycemic-index diets all showed measurable benefit for glycemic markers.
Nutrients2023
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11Nutrition
Mediterranean diet and glycemic control in type 2 diabetes
A 2025 meta-analysis of randomized controlled trials finding modest improvements in HbA1c, fasting glucose, and cardiometabolic markers with Mediterranean dietary patterns.
Nutrients2025
Read on PMC →
12Lifestyle
Optimal dose & type of physical activity for glycemic control
A dose-response meta-analysis modeling how much and what kind of physical activity most improves HbA1c in people with type 2 diabetes.
Diabetes Care2024
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13Lifestyle
Sleep amount & sleep quality and glycemic control in type 2 diabetes
Both short and long sleep duration, and poor sleep quality, were associated with meaningfully higher HbA1c across the studies reviewed.
Sleep Medicine Reviews2017
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14Lifestyle
Sleep features and the risk of type 2 diabetes mellitus
A 2025 meta-analysis linking short sleep, long sleep, poor sleep quality, and evening chronotype to increased type 2 diabetes risk.
Annals of Medicine2025
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15Diabetes Education
Continuous glucose monitoring in adults with type 2 diabetes
A systematic review and meta-analysis on how CGM use relates to HbA1c and time-in-range — background education, not a claim about Gluco6.
Diabetologia2024
Read on PMC →
16Diabetes Education
Chronic complications of diabetes & "metabolic memory"
Explains why sustained glucose management matters over time, even after glycemic control is achieved — background on long-term complication risk.
Molecular Medicine2024
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17Clinical Guidance
American Diabetes Association — Standards of Care in Diabetes, 2026
The ADA's current guidance advises that routine supplementation with micronutrients or herbs/spices is not recommended for glycemic benefit absent a diagnosed deficiency — important context for reading this whole page.
Diabetes Care2026
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